DEPARADOL SP TABLET

INTRODUCTION

• Deparadol SP tablet is a combination of Aceclofenac, Paracetamol, and Serratiopeptidase which belongs to a group of medicines called Nonsteroidal anti-inflammatory agents, Analgesics & Antipyretics, and Proteolytic enzymes, respectively. It is used to provide relief from inflammation and pain due to bone and soft tissue injury in affected individuals.
• It is also used to reduce high temperature and provide relief from cold (while sneezing) in affected individuals. The medicine is also indicated for use to resolve post-operative inflammation, oedema, and pain which is also used to provide relief from illnesses such as headache, moderate migraine, and musculoskeletal pain.
• Deparadol SP tablet is not recommended for use in patients allergic to aceclofenac, paracetamol, serratiopeptidase. It is also not recommended for use in patients having active/recurrent peptic ulcer/haemorrhage (bleeding), severe heart, liver or kidney diseases. 
• Before taking Deparadol SP tablet, inform your doctor if you suffer from uncontrolled high blood pressure, diabetes, hyperlipidaemia (high-fat level in blood), gastrointestinal diseases such as ulcerative colitis (inflammatory bowel disease), and/or aseptic meningitis (inflammation of the brain).
• Deparadol SP tablet is not recommended for use in pregnant and breastfeeding women. It is also not recommended for use in children and adolescents (below 18 years). Consult your doctor before taking the medicine.
• The most common side effects of taking Deparadol SP tablet are abdominal pain, nausea, vomiting, diarrhoea, flatulence, constipation, indigestion, and/or dizziness. Consult and inform your doctor if any of these symptoms gets worse.

USES OF DEPARADOL SP TABLET

• Provides relief from inflammation and pain due to bone and soft tissue injury in affected individuals
• Reduces fever and provides relief from cold (while sneezing) in affected individuals
• Reduces post-operative inflammation, oedema, and pain which also provides relief from illnesses such as headache, moderate migraine, and musculoskeletal pain

HOW DEPARADOL SP TABLET WORKS

• Deparadol SP tablet helps to reduce inflammation and provides relief from pain, where Aceclofenac and Paracetamol reduce pain and fever by blocking certain chemical messengers in the brain, and Serratiopeptidase promotes healing by breaking down abnormal proteins at the site of inflammation thereby healing the infected site in affected individuals.

DIRECTIONS FOR USE

• Take Deparadol SP tablet as advised by your physician. Swallow Deparadol SP tablet with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition..3

SIDE EFFECTS OF DEPARADOL SP TABLET

COMMON

• Inflammation of stomach
• Inflamed skin, itchy skin, red itchy welts, rash
• Nephrotoxicity (deterioration of the kidney due to drugs) that includes interstitial nephritis (kidney disorder), nephritic syndrome (kidney disease marked by blood in urine) and renal failure
• Abnormal liver function, inflamed liver and signs of jaundice such as yellowing of eyes and skin
• Neurological effects such as visual disturbances, optic neuritis (inflammation of the optic nerve of the eye), headaches, paraesthesia(abnormal sensation), reports of aseptic meningitis (inflammation of the brain) especially in patients with existing autoimmune disorders, such as sle and mixed connective tissue disorders with symptoms( such as stiff neck, headache, nausea, vomiting, fever or disorientation, depression, confusion, hallucinations, tinnitus, vertigo, dizziness, malaise, fatigue and drowsiness)
• Haematological effects such as thrombocytopenia (low platelet level), neutropenia (low white blood cell count), agranulocytosis (condition marked by inability to make white blood cell), aplastic anaemia (bone marrow disorder) and haemolytic anaemia (red blood cell count)

UNCOMMON

• Inflammation of stomach
• Inflamed skin, itchy skin, red itchy welts, rash
• Nephrotoxicity (deterioration of the kidney due to drugs) that includes interstitial nephritis (kidney disorder), nephritic syndrome (kidney disease marked by blood in urine) and renal failure
• Abnormal liver function, inflamed liver and signs of jaundice such as yellowing of eyes and skin
• Neurological effects such as visual disturbances, optic neuritis (inflammation of the optic nerve of the eye), headaches, paraesthesia(abnormal sensation), reports of aseptic meningitis (inflammation of the brain) especially in patients with existing autoimmune disorders, such as sle and mixed connective tissue disorders with symptoms( such as stiff neck, headache, nausea, vomiting, fever or disorientation, depression, confusion, hallucinations, tinnitus, vertigo, dizziness, malaise, fatigue and drowsiness)
• Haematological effects such as thrombocytopenia (low platelet level), neutropenia (low white blood cell count), agranulocytosis (condition marked by inability to make white blood cell), aplastic anaemia (bone marrow disorder) and haemolytic anaemia (red blood cell count).

RARE

• Signs of exfoliative and bullous dermatoses (autoimmune skin disorder) including epidermal necrolysis and erythema multiforme such as lesions that crust over, areas of thickened skin, fever, and weakness
• Anaemia, signs of vasculitis (inflammation of blood vessels) such as fever, weakness, weight loss
• Signs of anaphylactic reaction (life-threatening allergic reaction) such as lightheadedness, wheezing, fast heartbeat
• Face swelling, visual disturbance, shortness of breath
• Skin rash with disease/fever
• Stop taking Deparadol SP tablet and contact your doctor if you experience any of the following side effects:
• Signs of serious skin reactions (exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis) such as skin rash, mucosal lesions.